MEDRADSC 2Z03 Lecture Notes - Lecture 26: Cribriform Plate, Esthesioneuroblastoma, Carcinoma
29 Jun 2016
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Document Summary
Mri of the cranium demonstrated obstruction of the nasal cavity, sphenoid and frontal sinuses with a mass. The mass is hypointense on t1 wi, hyperintense on t2. There is no evidence of destruction of cribriform plate and extension into cranium. On the last image also strongly enhancing subcortical metastatic nodules in the parietal and occipital lobes are seen, a very rare finding. Esthesioneuroblastoma (enb) is an uncommon malignant neoplasm of neural crest origin arising from the olfactory sensory epithelium in the roof of the nasal fossa. Once arisen, enb tends to spread submucosally in all directions to involve the paranasal sinuses, nasal cavity, and surrounding structures. The tumor is locally aggressive, and local recurrence strikes in up to 68% of cases regardless of initial treatment protocol. Enb also metastasizes widely by both hematogenous and lymphatic routes, with the neck being the most common site. Symptoms are typically present for months, and sometimes for years before presentation.
