MEDRADSC 3U03 Lecture Notes - Lecture 13: E2F, P21, Dna Replication
4 Jan 2017
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Document Summary
Normal cellular genes that can be converted into oncogenes. Normal genes that make essential contributions to the regulation of cell proliferation and survival. Gain of function mutation can alter proto-oncogenes to induce tumor formation. Ras oncogenes have been detected in cancers of the bladder, lung, colon, pancreas and thyroid. Amplification can be 10, 100 or 1000 x, and typically yields oncogenes that produce normal proteins, but in excessive quantities. Myc gene family one of the most commonly encountered oncogenes to arise by amplification. Myc have been detected in breast, ovary, uterine cervix, lung and esophagus. Erbb2 is an amplified gene in about 25% of breast and ovarian cancers. Herceptin is designed to counteract the effect of this gene. If amplified to (cid:883)(cid:882) times, then that"s gonna be a very aggressive gene. Associated with ~90% of all cml cases. Bcr-abl fusion gene acts as an oncogene coding for an abnormal protein. Chromosomal translocation is involved with burkitt"s lymphoma although a.
