MEDRADSC 1B03 Lecture Notes - Lecture 14: Vitamin B12 Deficiency, Megaloblastic Anemia, Sickle-Cell Disease

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 1B03
• Professor: Sandra Charbonneau

Document Summary

Caused by reduction in o2 transport in blood bc of a decrease in hemoglobin production, a decrease in rbcs, or both. O2 deficits cause decrease in energy; cell division then gets shut down, then body tries to compensate by increasing heart rate (tachycardia) & peripheral vasoconstriction to keep blood w in trunk/head; if those don"t work, general s&s occur. Decrease regeneration of epithelial cells - in gi tract, there are a lot of absorption processes going on, if we know the body needs ca, iron, b12, it will impact absorption. If o2 levels fall enough, get severe anemia & can cause angina (chest pain) & may lead to chronic heart failure. A deficiency of a required nutrient; typically iron or b 12. Bone marrow function is impaired; affects # of rbc available. Excessive destruction of rbcs = hemolytic anemia; seen in sickle cell anemia. Iron deficiency anemia/microcytic hypochromic (small cells lacking colour) anemia.