MEDRADSC 1B03 Lecture Notes - Lecture 16: Diabetic Coma, Insulin Resistance, Diabetes Mellitus Type 2
29 Jun 2016
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Document Summary
Deficit of insulin secretion by islets of langerhans or by insulin resistance. Type 1: (juvenile diabetes or insulin diabetes mellitus iddm) dependent. Results from insulin deficiency due to the beta cell destruction (autoimmune process) Type 2: (non-insulin dependent dm or mature onset diabetes) Due to decreased effectiveness of insulin or relative deficit: decreased production of beta cells, increased insulin resistance, increased glucose production by the liver. Older adults develops gradually, patient"s often overweight. Increasing incidence in teens and young adults (as metabolic syndrome: metabolic syndrome marked by obesity, hypertension, insulin resistance. Milder form of disease/ can be controlled by diet or stimulation of beta cells in increased insulin production. Initial stage of insulin deficit: decreased transport of insulin, decreased use of glucose, blood glucose levels rise hyperglycemia, excess glucose in urine glucosuria, polyuria, dehydration results, polydipsia (thirst, polyphagia (stimulated appetite) Progressive effects: metabolic changes (m/c in type 1 dm: catabolism of fats and proteins.
