NURSING 2LA2 Lecture Notes - Lecture 6: Genetic Predisposition, Serotonin Transporter, Psychoneuroimmunology

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Amygdala: receives signals (stress) from the temporal and occipital lobes of the cortex and communicated with the hypothalamus and limbic system, responsible for aggression and fear. Biogenic amine hypothesis: decreased levels of neurotransmitters serotonin and norepinephrine in the synaptic cleft is caused by decreased pre-synaptic release, decreased post-synaptic sensitivity, depression that causes low serotonin, and/or low serotonin that causes depression. Dopamine: neurotransmitter found in the substantia nigra (midbrain region), usually excitatory- responsible for motivation, thought, emotional regulation, and sensations of pain and pleasure. Overactivity in schizophrenia and psychotic disorders, underactivity in people (cid:449)ith parki(cid:374)so(cid:374)"s disease. Electroconvulsive therapy (ect): therapy electrically stimulates a generalized seizure, down regulating b-adrenergic receptors, lowering the stress response. Gamma aminobutyric acid (gaba): inhibits nerve transmission in the brain, implicated in anxiety disorders- decreased levels of inhibition cause an overexpression of normal situations. Light therapy: uses artificial light to influence the production of melatonin and the function of the catecholamine systems.

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