NURSING 2LA2 Lecture : Inflammation.docx
13 Apr 2014
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Document Summary
Goals include: movement of all necessary blood and cellular components to the site of injury or insult, delivery of nutrients and blood cells to the site of injury, dilution, confinement and elimination of the offending agents, stimulate and assist the immune system, promotion of healing with generation of new tissue. Endothelial cells: cells lining blood vessel walls, space between them is tight, limiting movement of cells and particles across the wall, they produce antiplatelet and antithrombotic agents, vasoconstrictors and vasodilators, regulate leukocyte movement and immune cell proliferation and participate in the repair process. Monocytes/macrophages: monocytes are leukocytes that also contain lysosomes, they respond to inflammation and take up residence in the tissues as the mature macrophage, they arrive later than, and eventually replace neutrophils, they produce vasoactive mediators and engulf more material than neutrophils, their lifespan is 3 4x longer than neutrophils, they also interact with the immune system.
