PSYCH 2AP3 Lecture Notes - Cerebrospinal Fluid, Dopamine Hypothesis Of Schizophrenia, Dopamine Receptor D2

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Effective drugs (phenothiazines) block dopamine receptors in animals. Dopamine antagonists reduce symptoms: chemicals that do this have such strong side effects that they are almost never used. Van kammen et al (1981) reviewed 12 studies of amphetamine administration: Mao inhibitors do not worsen schizophrenic symptoms (brenner & shopsin, D2 receptor do have impact on positive symptoms of schizophrenia, if you block d2 receptors you see an amelioration in positive symptoms. Etiology: types i and ii type i: excess dopaminergic activity. Probably more of a genetic basis type ii: neuron loss in the brain. Negative symptoms predominate: enlargement in cerebral ventricules. Less likely to have a family history of schizophrenia. May be due to perinatal brain damage. Mz is much higher than dz concordance rate. Something else going on in addition to the genetics fischer (1973): mz=56%; dz:26% Etiology: genetic family child (both parents affected) = 46% child (one parent, one sib affected) = 17% child (one parent affected) = 12%

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