Class Notes (835,722)
Canada (509,348)
Psychology (5,217)
PSYCH 2E03 (70)
Lecture

Internal Ear Orchestra.docx

5 Pages
63 Views
Unlock Document

Department
Psychology
Course
PSYCH 2E03
Professor
Gautam Ullal
Semester
Fall

Description
November 21 , 2012 Psych 2E03: Sensory Processes Internal Ear Orchestra Organ of Corti - organ of corti resting on the basilar membrane Basilar membrane and the resonating frequencies Organ of Corti Hair cells (of Corti) The organ of Corti - key structures:  basilar membrane vibrates in response to sound and supports the organ of Corti  inner and outer hair cells are the receptors for hearing  tectorial membrane extends over the hair cells Hair cell cilia and top-links Hair cell-transduction The organ of Corti - transduction takes place by:  cilia bending in response to movement of organ of Cort and the tectorial membrane  movement in one direction opens ion channels  movement in the other direction closes the channels  this causes bursts of electrical signals Defective tip-links associated with certain congenital deafness Cochlear microphonic-potentials Innervation pattern of inner hair cell (IHC) & outer hair cell (OHC) - whereas IHC has afferent sensory innervation, OHC has afferent (sensory) as well as efferent (motor) innervation Muscle inside a hair cell (outer hair cell) An outer hair cell contracts Prestin contractile protein immunolocalized in the cell membrane of outer hair cells Prestin the ultra-fast contractile protein in the cell membrane of outer hair cells 9 1 1 o i r i U r s a c Figure 3. A) Higher magnification SEM of the organ of Corti at the apical region. OHCs are cylindrical and straight. The length of these M cells is around 50 µm. B) A section cut more basal in the cochlea showing parvalbumin labelling in OHCs and IHCs. Neurons beneath b l m o the hair cells are also positive. C) Prestin is expressed exclusively in OHCs. D) Double-labelling shows no expression of prestin in IHCs . s while OHCs co-express parvalbumin and prestin (merge). Blue: DAPI nuclear staining. r l h n Prestin (shown red) confirmed in human OHC a r h p a r o F n Prestin in human cochlea 59 i r d d o n o D e M i u
More Less

Related notes for PSYCH 2E03

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit