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Lecture 10

4 Week 4 (Lecture 10-12) - Jan 28 - Psych 3F03.docx
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Department
Psychology
Course
PSYCH 3F03
Professor
Paul W Andrews
Semester
Winter

Description
LECTURE 10­12 PSYCH 3F03 Lecture 10  January 28, 2014 How is Insulin resistance triggered? − During infection, cytokines trigger insulin resistance − Inhibit insulin receptors on selected tissues − Thus, the signaling power of insulin is decreased in those tissues o Less glucose is taken from the bloodstream  − Resistance in the spleen would not occur, because it is needed in the immune system Why can your diet trigger the immune system? − Mechanistically, glucose is the preferred energy source of  − ­ − ­ − ­ Not all aspects of the diet trigger immune response − What seems to be important in modern diets that trigger immune response – sugars (glucose), some fatty acids (saturated, not unsaturated) o Saturated fatty acids are more likely to come from animal products; unsaturated fatty acids from plants Why do we store fat in adipose tissue? − Energy reserve for o Starvation o Infection o Pregnancy o Other conditions of energetic stress − During energetic stress – fat mobilized and converted into saturated fatty acids (FAs) for the body to use  o Not only fat that is mobilized; glucose from the liver is also mobilized during energetic stress Immune response is energetically expensive − Inactive immune system consumes about 23% of overall metabolism (large amount!) − When activated by infection, increases even further  o Sepsis > 50% − Where does energy come from is we’re not eating? o Less overall food consumption when sick – so where does energy come from? o Fatty acids stored in adipose tissue and glucose in liver Lymph nodes are important in the immune response − Found all over the body − Often concentrated in regions where pathogens are likely to be encountered o Eg/ oral cavity, tonsils, digestive tract, genitals – but also in peripheral limbs  − Embedded in adipose tissue – less likely to compete for energy with other tissues  Mobilization of fat and insulin­resistance − Immune response to infection requires both: o Down regulation of energy expenditure in n
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