PSYCH 1XX3 Lecture Notes - Lecture 9: Malar Rash, Pernicious Anemia, Stomach Cancer
19 May 2018
School
Department
Course
Professor
Autoiue Disease’s
Disease
Auto-antibodies
Features
SLE
Anti-sm
Anti Ro
Anti-LA
Anti-dsDNA
F:M = 9:1
Serositis, Oral ulcers, Arthritis,
Photosensitivity, Blood changes, Renal
involvement, ANA, Immunological changes,
Neuro stuff, Malar rash, Discoid rash
Drug-induced lupus
Anti-Histone
– Procainamide
– Hydralazine
– Isoniazid
– Clindamycin
Sjogrenʼs Syndrome
Ant-LA
Anti-Ro
RA
Anti-CCP
Diffuse Scleroderma
Anti-SCL 70
CREST + Pulmonary fibrosis, Renal disease,
Polyarthritis, Myopathy/muscle atrophy
Limited
Scleroderma/CREST
Anti-centromere
Calcinosis, Raynauds Phenomenon,
Osephageal dismotility, Sclerodactyly,
Telangectasia
Dermatomyositis/
polymyositis
Anti-Jo-1
Wegnerʼs
granulomatosis
C-ANCA
Pernicious anaemia
90% anti‐parietal cell
antibodies
50% anti‐IF antibodies
Autoimmune attack on parietal cells - atrophic
gastritis & lack of intrinsic factor
↓serum vit. B12
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