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Lecture 15

PSYCH 1XX3 Lecture Notes - Lecture 15: Hemolytic Anemia, Vascular Permeability, Transplant Rejection


Department
Psychology
Course Code
PSYCH 1XX3
Professor
Joe Kim
Lecture
15

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Complement deficiencies
Allergy
Type
Mechanisms
Examples
Type I
IgE-mediated hypersensitivity
Allergies, Asthma
Type II
IgG/IgM reactive with self
antigen
Grae’s disease, Goodpastures
Syndrome, Autoimmune
haemolytic anaemia
Type III
Immune complexmediated
damage
Lupus, Polyarteritis Nodosa
Type IV
T-cell mediated damage/delayed
hypersensitivity
Rheumatoid, IDDM, MS,
Transplant rejection
Clinical Features
Primary
o Skin changes
o Smooth muscle contraction
(lungs/gut)
o Mucus secretion (lungs)
o Vascular permeability (shock)
Delayed
o Oset ‐4 hours after exposure,
o Lasts many days
o Inflammatory cell infiltration
(associated tissue damage)
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