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BIOL 2202 Lecture Notes - Lecture 2: Electrochemical Gradient, Resting Potential, Atp Hydrolysis

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scarletlouse511
27 Jun 2017
School
Mount Royal University
Department
Biology
Course
BIOL 2202
Professor
Kumar

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Document Summary

Chapter 12: transport across cell membranes: overview, transmembrane transport, membrane potential, nerve cell signalling, overview. Movement of a molecule down its concentration gradient. Rate of diffusion across a lipid bilayer depends on: Small, nonpolar molecule move the fastest (oxygen, n2, steroids, hormones) small, uncharged polar molecules (water, ethanol) larger, uncharged, polar (glucose, amino acids) ions. Molecules that cant diffuse across the membrane must be transported. Polar substances (charged or organic molecules) must use specific membrane transport proteins. The transporter is the one which will have one end open and one end closed and the channel has both ends open. Remember water molecules are small, polar (uncharged) molecules they can diffuse through. Isotonic solution water potential is equal between sides (water potential is where. Hypotonic solution water potential is higher outside. Movement of water across a membrane water wants to move. The higher water potential means it wants to move)

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Related Questions

1. The plasma membrane of liver cells contains a glucose uniportthat transports glucose by facilitated diffusion. When the[glucose] is higher inside the liver cell than the [glucose]outside the liver cell, the glucose uniport will

A. couple the transport of glucose out of the cell to thehydrolysis of ATP

B. couple the transport of glucose into the cell to thehydrolysis of ATP

C. switch to a closed conformation, allowing no transport ofglucose

D. transport glucose out of the cell by passive transport

E. transport glucose in of the cell by passive transport

2. Unlike the positive charged ion shown in the middle diagramof figure 11-4B, K+ is higher in concentration inside the cell. Howwill the membrane potential of a cell at rest (shown in both themiddle and right-hand diagrams of Figure 11-4B) affect theelectrochemical gradient for K+?

A. The membrane potential will increase the electrochemicalgradient

B. The membrane potential will decrease the electrochemicalgradient

C. The membrane potential will have no effect on theelectrochemical gradient

3. Which of the following proteins carries out activetransport?

A. gluclose symport

B. Bacteriorhodopsin

C. ABC transporter

D. NA K pump

E. All of the above

4. Aquaporin will not transport Na+ ions because

A. Two asparagine residues in the channel prevent the passage ofNa+ ions by binding the oxygen of each water molecule as it passesby

B. Na+ ions are repelled by the positive charges at the entranceto the channel

C. Na+ ions cannot make contact with the carbonyl (C=O) groupson all four sides of the channel

D. The passage of Na+ ions is energetically unfavorable becauseone side of the channel is hydrophobic in nature

5. The acetylcholine receptor is different from other channelproteins we have discussed, such as the K+ leak channel,because

A. The acetylcholine channel is composed of a single polypeptiderather than multiple subunits

B. The acetylcholine channel transports Na+ ions against theconcentration gradient for sodium

C. The acetylcholine channel has a much smaller diameter thanother channel proteins

D. The acetylcholine channel transports ions with theirassociated shell of water molecules

E. The acetylcholine channel is always open, and never switchesto a closed conformation

6. After opening briefly along the axon of a neuron,voltage-gated ion channels switch to an inactivated conformationthat slowly returns to the original closed conformation of theprotein. This slow change in conformation, requiring about amillisecond, is important because

A. all of the ions that were transported across the membranewhen the ion channels were open must be actively transported backto the other side of the membrane, restoring the originalconcentration gradient, before the ion channels can open again

B. ATP hydrolysis is necessary to drive this energeticallyunfavorable change in conformation

C. it prevents the action potential from reversing direction andtraveling back toward the cell body of the neuron

D. the channel protein must be dephosphorylated in order tocomplete the transport process and return to the originalnonphosphorylated conformation

True or False? True False
1. Proteins rapidly pass artificial membrane (liposome).--------------------------------------------------------------------------------------( ) ( )
2. Amphiphatic detergent such as SDS spontaneously forms bilayer inwater. ------------------------------------------------------------( ) ( )
3. Cholesterol does have a hydrophilic head and hydrophobic tail.-------------------------------------------------------------------------( ) ( )
4. Fat molecules are one of the major components of the plasmamembrane.------------------------------------------------------------- ( ) ()
5. Phospholipid molecules such as phosphatidylcholine spontaneouslyform bilayer. ----------------------------------------------------( ) ( )
6. Flippase facilitates lateral movement of phospholipids withinthe plane of the membrane.----------------------------------------- ( ) ( )
7. Glycolipids make bilayer less permeable to small water solublemolecules.----------------------------------------------------------- ( ) ()
8. Membrane inner leaflet is enriched with phosphatidylcholine,Sphingomyelin, and Glycolipid. -----------------------------------( ) ( )
9. Plasma membrane proteins can have an enzyme activity.--------------------------------------------------------------------------------( ) ( )
10. A single pass membrane protein must have an amphiphatic alphahelix.-------------------------------------------------------------- ( )( )
11. Plasma membrane proteins can be linked to a lipid molecule atthe outer leaflet of the plasma membrane. --------------------- ( )( )
12. The lateral motility of membrane proteins can be restricted bytight junctions.------------------------------------------------------ ( ) ()
13. Channel proteins have specific binding sites for ions and thusslower than carrier proteins.--------------------------------------- ( ) ( )
14. An antiport would function as a symport if its orientation inthe membrane were reversed. ---------------------------------------( ) ( )
15. A transmembrane pore can be formed by multiple amphipathicalpha helices. ----------------------------------------- ( ) ()
16. Porin proteins form water-filled channels in the outer membraneof a bacterium and are mostly composed of beta sheets. ---- ( ) ()
17. Glucose uniporters localize at the apical side of theintestinal epithelium.------------------------------------------------------------ ( ) ()
18. GAP junction is a selective pore for anions.-----------------------------------------------------------------------------------------------( ) ( )
19. A voltage-gated Na+ channel adopts only two conformationstates: open and closed.----------------------------------------------- ( ) ( )
20. Voltage gated K+ channel opens faster than the Voltage gatedNa+ channels.-------------------------------------------------------- ( ) ()
21. Opening of chloride channel at the synapse will help to fire anaction potential.------------------------------------------------------ ( ) ()
22. The nuclear pore complex forms a gate through which moleculespass the nucleus uni-directionally. -------------------- ( ) ()
23. A completely folded protein is imported into a mitochondrionthrough a large non-selective pore.--------------------------------- ( ) ( )
24. ER signal sequence contains multiple lysine and arginineresidues.----------------------------------------------------------------------( ) ( )
25. The plasma membrane is a sorting station of inward endocyticpathway.---------------------------------------------------------------- () ( )
26. The trans Golgi functions as a sorting station of outwardsecretory pathway.----------------------------------------------------------- ( ) ()
27. Vesicles budding from ER are coated with Clathrin.----------------------------------------------------------------------------------------( ) ( )
28. RabGTPases and tethering proteins are the major specificitydeterminant of vesicle transport system. --------------------------( ) ( )
29. v-SNARE proteins are one of the tethering proteins.------------------------------------------------------------------------------------( ) ( )
30. In secretory cells, the constitutive and regulatory pathways ofexocytosis diverge at the cis Golgi network. ------------------ ( )( )
31. Many proteins are posttranslationally glycosylated at tyrosineresidues in the ER.------------------------------------------------- ( ) ( )
32. Cells import LDL molecules exclusively through pinocytosis.-------------------------------------------------------------------------( ) ( )
33. Cells recycle LDL receptors from lysosome to the plasmamembrane.----------------------------------------------------------------- () ( )
34. Phagosomes fuse with late endosome.------------------------------------------------------------------------------------------------------( ) ( )
35. Small vesicles from ER near the plasma membrane can fuse withthe plasma membrane upon bypassing Golgi apparatus. -- ( ) ()
36. If a Sec mutant showed an accumulation of newly synthesizedproteins at ER,
then the Sec gene is likely a component of vesicle-buddingmachinery of trans-Golgi network.------------------------------------ ( ) ( )
37. A signal recognition particle is a single pass trans-membraneprotein of the ER membrane.---------------------------------------- ( ) ( )
38. Typical animals cells display higher levels of intracellularsodium than extracellular compartments.------------------------------ ( ) ( )
39. Typical animals cells display higher levels of intracellularchloride than extracellular compartments.----------------------------- ( ) ( )
40. The Na-K Pump is a GTPase that can adopt active and inactiveconformational states.----------------------------------------------- ( ) ( )
1. Phospholipase
C-­-ß
produces
phosphatidylinositol
3,4,5-­-trisphosphate
and
diacylglycerol.
(
)
(
)
2. PDGF
activates
GPCR.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
3. Rho
is
an
example
of
heterotrimeric
G
proteins.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­-
(
)
(
)
4. All
members
of
the
G
protein
coupled
receptors
interact
with
small
GTPase
Ras.
-­--­--­--­--­--­--­--­--­--­-
(
)
(
)
5. Adrenaline
is
an
example
of
the
ligands
for
the
RPTK
family.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
6. Ras
GEF
activates
RPTK.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
7. PH
domain
containing
proteins
bind
to
activated
EGFR.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
8. Ligands
for
GPCR
proteins
induce
dimerization
of
the
receptor.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
9. Grb2
is
an
adaptor
protein
that
binds
to
a
phospho-­-tyrosine
residue
of
activated
RPTK
through
a
PH
domain.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
10. When
a
cell
is
expressing
a
large
number
of
dominant
negative
EGFR
proteins,
an
introduction
of
a
constitutively
active
Ras
mutant
will
allow
EGF
signaling.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
11. PI3K
generates
phosphatidylinositol
3,4,5-­-trisphosphate
from
IP3.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
12. Calcium
inhibits
PKC.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
13. cAMP
activates
PKA.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
14. The
MAP
kinase
ERK
inhibits
MAP
kinase
kinases.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­-
(
)
(
)
15. cAMP
is
an
example
of
a
first
messenger.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­----­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
16. All
7-­-Transmembrane
receptors
are
G
Protein
Coupled
Receptors.
-­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
17. Both
Ga
and
Gß
subunits
of
the
heterotrimeric
G
protein
can
mediate
GPCR
signaling.
-­--­--­-
(
)
(
)
18. Both
Ga
and
Gß
subunits
of
the
heterotrimeric
G
protein
have
GTPase
activity.
-­--­--­--­--­--­--­--­--­--­--­--­-
(
)
(
)
19. The
Gas
subunit
of
the
heterotrimeric
G
protein
suppresses
the
function
of
Adenylyl
cylase.
(
)
(
20. All living things must maintain a constantinternal environment to function properly through the process of__. (Points : 2)
metamorphosis
alkalosis
homeostasis
cryogenesis
Question 21.21. Glucose, fructose, sucrose,starch and glycogen are all examples of ___. (Points : 2)
proteins
carbohydrates
lipids
nucleic acids
Question 22.22. Some insects can "walk onwater" because __. (Points : 2)
water has a high surfacetension
water is adhesive
water istransparent
water expands when itfreezes
Question 23.23. To overcome an energy barrierbetween reactants and products in a chemical reaction, energy mustbe provided to get the reaction started. This energy is called ___energy. (Points : 2)
potential
reaction
initiation
activation
Question 24.24. Where in the cell doesglycolysis takes place? (Points : 2)
lysosomes
cytoplasm
mitochondria
nucleus
Question 25.25. Photosynthesis uses sunlightto convert water and carbon dioxide into __. (Points : 2)
carbon dioxide andwater
oxygen and sugars
proteins and sugars
carbon dioxide andoxygen
Question 26.26. The _____ of photosynthesisare the _____ of cellular respiration. (Points : 2)
electrons, protons
pigments, products
products, reactants
elements, atoms
Question 27.27. The energy currency of thecell is __. (Points : 2)
glucose
ATP
starch
glycogen
Question 28.28. When blood glucose levelsdecrease (as between meals), what reserves are tapped first?(Points : 2)
glycogen
fats
steroids
amino acids
Question 29.29. When glucose is used as anenergy source, the largest amount of ATP is produced by the ____portion of the entire respiratory process. (Points : 2)
glycolytic
Kreb's cycle
acetyl-CoAformation
electron transportchain
Question 30.30. Pyruvic acid can be regardedas the end product of ____. (Points : 2)
glycolysis
fermentation
the Kreb cycle
the electron transportchain
Question 31.31. How can one increase the rateof a chemical reaction? (Points : 2)
Increase the activationenergy.
Cool the reactants.
Decrease the pH.
Add an enzyme(catalyst).
Question 32.32. A prokaryote has ___. (Points: 2)
membrane-boundorganelles
nucleus
mitochondria
a cell membrane
Question 33.33. Unlike animal cells, plantcells have __. (Points : 2)
cell membranes
cell walls
chromosomes
mitochondria
Question 34.34. Which of the followingrequires energy to move molecules across the cell membrane? (Points: 2)
diffusion
osmosis
active transport
passive transport
Question 35.35. The ___ is the site of proteinsynthesis. (Points : 2)
nucleus
ribosome
mitochondrion
cytoskeleton
Question 36.36. Diffusion of water through asemipermeable membrane is called __. (Points : 2)
osmosis
diffusion
active transport
passive transport
Question 37.37. Which component of a cellmembrane is likely to function as a transporter? (Points : 2)
cholesterol
lipids
proteins
carbohydrates
Question 38.38. If potato slice is placed indistilled water, the cells would most likely __. (Points : 2)
lose water and becomelimp
neither take up water orlose water
take up water andswell
transport water into thecell by active transport.
Question 39.39. The chloroplast functions in___. (Points : 2)
protein synthesis
lipid storage
DNA replication
photosynthesis
Question 40.40. The fluid mosaic modelpresents the modern view of ___. (Points : 2)
the cell membranestructure
chromosome movementduring mitosis
protein synthesis
ATP production
Question 41.41. During which stage of mitosisdo nucleoli reappear and the nuclear membrane reforms? (Points :2)
prophase
metaphase
anaphase
telophase
Question 42.42. During which stage of mitosisdo chromatids separate to form two sets of daughter chromosomes?(Points : 2)
prophase
metaphase
anaphase
telophase
Question 43.43. Which of the following is thelongest stage of mitosis? (Points : 2)
prophase
metaphase
anaphase
telophase
Question 44.44. When during the cell cycle isDNA replicated? (Points : 2)
metaphase
Synthesis phase (S)
G1
cytokinesis
Question 45.45. A cell with 10 chromosomesundergoes mitosis and cell division. How many daughter cells areproduced and what number of chromosomes do they have? (Points :2)
4 daughter cells, 20chromosomes each
4 daughter cells, 5chromosomes each
2 daughter cells, 10chromosomes each
2 daughter cells, 5chromosomes each
Question 46.46. Maize (corn) has a haploidnumber of 10. How many chromosomes are in a zygote of maize?(Points : 2)
5
10
20
Not enough informationprovided
Question 47.47. Crossing over is one of themost important events in meiosis because __. (Points : 2)
homologous chromosomesare separated into different daughter cells
the number of chromosomesallotted to each daughter cell must be halved
sister chromatids must beseparated into different daughter cells
it produces new arrays ofalleles on chromosomes and contributes to genetic diversity
Question 48.48. While viewing stained onionroot tip cells you notice that distinct chromosomes cannot beobserved in most of the cells. This is because most of the cells___. (Points : 2)
were killed whilepreparing the slide
are in Interphase
are in metaphase
are undergoingMeiosis
Question 49.49. Each offspring cell producedby binary fission contains __. (Points : 2)
half the chromosomes ofthe original cell
twice as many chromosomesas the original cell
an independent assortmentof the original cell's chromosomes
an identical copy of theoriginal cell's chromosome.
Question 50.50. A DNA strand has the sequenceA-C-A-G-C-C-G-T-A. What would be its complementary strand? (Points: 2)
G-T-G-A-T-T-A-C-G
A-C-A-G-C-C-G-T-A
T-G-T-C-G-G-C-A-T
U-G-U-C-G-G-C-A-U