PSYC 2275 Lecture Notes - Lecture 5: Acetylcholinesterase, Reuptake, Selective Serotonin Reuptake Inhibitor
7 Oct 2016
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Psyc 2275 - lecture 5 - neurophysiology (continued) Mylienated neurons: faster transmission and is more efficient: saltatory conduction has two advantages (faster transmission and uses lower energy) Local potentials: excitatory post-synaptic potentials (epsp) are graded potentials that depolarize the membrane, inhibitory post-synaptic potentials (ipsp) are graded potentials that hyperpolarize the membrane. Post-synaptic potential: change in membrane potential caused by synaptic input. Summation: act or process of adding; addition. Epsp and isis added at the axon hillock: spatial and temporal. Different places on the neuron (spatial) or time (temporal) Action potentials last 1-2ms, epsp and ipsp last up to 100ms: temporal summation: potentials generated at different times. Voltage-gated calcium channels: calcium ions trigger vesicle fusion and neurotransmitter release. Synaptic transmission - binding of neurotransmitter to receptor: ligand (binds to receptors, receptor, ligand-receptor binding happens like a key in a lock. Ionotropic receptor: binding site on the ion channel, when a neurotransmitter binds, the ion channels open (ligand-gated ion channel, 5 subtypes.
