BIOC 1430 Lecture Notes - Lecture 17: Nitrogen Balance, Pancreatic Juice, Nitrogen Cycle

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In the mouth, saliva does not contain any enzymes that digest proteins. Dietary protein entering the stomach causes release of gastrin by the stomach mucosa cells. Hcl acid acts as an antiseptic killing most bacteria, denatures the globular proteins making peptide bonds more accessible to digestive enzymes, and activates pepsinogen to pepsin. Proteins are hydrolyzed by the action of pepsin. 10% of peptide bonds in proteins are hydrolyzed, producing a variety of polypeptides. Partially digested proteins passes from the stomach to the small intestine, where digestion is completed. This stimulates production of the hormone secretin, which stimulates pancreatic production of. Enzymes trypsin, chymotrypsin and carboxypeptidase in pancreatic juice attacks peptide bonds. Enzyme aminopeptidase secreted by intestinal mucosal cells also attack peptide bonds. Proteins are completely broken down to amino acids. Absorption of these free amino acids through the intestinal walls requires active transport. Free amino acids enter the blood stream, which distributes them throughout the body.

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