BIOL 3052 Lecture Notes - Lecture 7: Lipopolysaccharide, Superantigen, Erythroderma
27 Jan 2017
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Difference between anthrax bacilli and anthracoid bacilli & virulence factors of. Virulence factors of staphylococcus: cell wall associated. Capsular serotypes 5 and 8 are most frequently associated with bacteremia and infections: cell surface associated. Basis for coagglutination test, used in laboratories for organisms identification (e. g. , gonococci and streptococci) Binds to fc region of all human igg subclasses except igg3. Detected by slide test for bound coagulase: extracellular enzymes. Clots plasma in the absence of calcium. Reacts with coagulase-releasing factor (crf) and the resulting complex (staphylothrombin), converts fibrinogen to fibrin. Eight types (most common type is a) Detected by tube test for free coagulase. Binds to plasminogen and activates it to the fibrinolytic enzyme plasmin. Plays role in the invasiveness of s. saprophyticus in the urinary tract. Aids in invasiveness by breakdown of hyaluronate rich tissue barriers (accounts for persistence of staphylococcus in tissues) Sphingomyelinase activity on rbcs (responsible for camp test) Surfactant on various cells: erythrocytes, leucocytes, bacterial protoplasts (cid:630)-hemolysin.
