BIOL 3500 Lecture 2: 3 connective tissue
7 Oct 2016
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Connective tissues: cells, extracellular matrix: ground substance +fibers synthesized and secreted by connective tissue cells. Fills spaces between fibers and cells consists of: Hydrophilic, viscous macromolecules: glycosaminoglycans (gags, proteoglycans: very large macro-molecules composed of a core protein + gag adhesive glycoproteins, e. g. laminin, stabilize the ecm core p glycop. Collagen: most abundant protein in the human body. 15-20 types of collagen have been identified: collagen i most abundant. In h&e sections, collagen appears as pink wavy fibers (diameter : 2 to 10 m) primary function = add strength to the connective tissue. tendons, ligaments, bone, dermis, organ capsules, and loose connective tissue. tendons. Collagen: bundles of fine, threadlike subunits, the collagen fibrils. Collagen secreted by fibroblasts as procollagen cleaved off outside the cell to form collagen aggregates into fibrils fibers. All collagen fibrils and fibers have stripes at intervals of 64 nm along their length.
