PSYC 2800 Lecture Notes - Lecture 11: Cocaethylene, Cytochrome P450, Drug Delivery
18 Dec 2016
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The drug moves from the lungs into the bloodstream through capillary walls. Effects are rapid because blood moves quickly from the lungs to the brain. Absorption through the skin can provide slow, steady drug delivery (patches) Absorption through the mucous membranes occurs more rapidly (buccal membranes) Some drug molecules attach to protein molecules; they are inactive in this state. Free (unbound) drug molecules can move to sites of action in the body. Drugs vary in their affinity for binding with plasma proteins replace. So(cid:373)e drugs (cid:272)a(cid:374)"t (cid:272)ross the (cid:271)lood-brain barrier; they act only on peripheral nerves. Only lipid-soluble substances can leave capillaries in the brain. Many brain capillaries are covered with glial cells, also increasing the difficulty for compounds to pass out of the capillaries. Active transport systems may be needed to move chemicals in and out of the brain. Trauma and infection can impair the blood-brain barrier.
