BIOL 318 Lecture Notes - Lecture 5: Chemokine Receptor, Innate Immune System, Selectin
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Thursday september 20th 2018 (part 1) non-specific defenses. Non-specific interior defenses: once pathogen surmounts surface barriers, non-specific (innate) interior defenses come into, inflammation, phagocytosis, complement, interferon. Thursday september 20th 2018: released at site of inflammation facilitate both adherence of immune system cells to vascular endothelial cells and their migration through vessel wall into tissue spaces. Thursday september 20th 2018 underlying tissue (=diapedesis/transmigration/extravasation: important inflammatory mediators, proinflammatory cytokines, tumor necrosis factor alpha (tnf- ) C-reactive protein produced by liver activates complement system: acute phase response (apr): production of certain proteins and cells that appear in blood in early stages of disease (inflammation) Part of early defense against infection (before adaptive response begins: apr proteins: class of proteins made in the liver in response to inflammation (ex. Serum concentrations of these proteins increase (up to 100 fold) in inflammation (diagnostic) Crp recognizes and binds to molecular groups found on wide variety of bacteria and fungi (pattern recognition) activates complement (is an opsonin.