BIOL 318 Lecture Notes - Lecture 21: Natural Killer Cell, Innate Immune System, Adaptive Immune System

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Thursday november 22nd 2018: because class i expression is often decreased on altered self-cells, the killing signal predominates, leading to destruction, missing self model of differential recognition of target cells vs normal cells by nk. In the altered cell, mhc class i molecules are often reduced or eliminated, so inhibitory signal is not given and processes leading to target cell death are initiated. Infected, stressed, or tumor cells up-regulate expression of certain proteins that are recognized by activating receptors on nk cells. Immunological tolerance: tolerance prevents autoimmunity (immune response to your own ags, damage to body!) Immune system"s lack of response to self ag: prevents destruction of body"s tissues by its own immunological weapons, when immune tolerance fails and immune system attacks its own ag = autoimmune. Thursday november 22nd 2018: they fail thymic selection. Or: thymic selection, thymocytes must go through both positive and negative selection.

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