BCHM 310 Lecture 15: BCHEM 315 5:2

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R groups above plane of b sheet interaction w r groups of a-helix. Multiple b-a-b motifs assemble into a 3d fold. These motifs wrap into cylindrical 3d fold. Family of proteins w diverse functions: pores in memb, enzymes (active site to cat rxs) Folded protein stab by long range non-covalent interactions (h bonds, electrostatic, hydrophobic) Disulfide bonds cys-s-s-cys formed in ox enviro: globular proteins: single folded entities (single polypeptide chain folded in globular structure, multimodular proteins: comprise domains (regions w/n polypep chain that independently fold into a functional unit) Each domain has a function (can be similar or diff functions) 1= enzymatic domain, 2= sugar binding domain, 3= memb binding domain. Sugar binds 2 and 1 enzymatically breaks down, memb domain brings sugar to 2. Multiple complementary functions in a single protein which gives rise to functional synergy or cooperativity (function of 1 domain enhances function of another)

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