BCHM 310 Lecture 26: BCHEM 315 9:3
22 Dec 2018
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Increase in [h] leads to ph of 7. 2 means that his146 is protonated and have electrostatic interaction b/n his and asp94 stab the t state lung. Decr in [h] leads to a ph of 7. 6, his 176 is deprotonated loss of salt bridge, r state stab (high affinity) and incr o2 binding. Curve shifted r for a ph of 7. 4 and shifted l for a ph of 7. 2. P50 po2 req to sat hb shigt w ph (bohr effect) Effect of po2 and ph on o2 affinity occurs simultaneously: decr ph, decr o2 affinity, decr po2, decr o2 affinity. Most co2 transported from tissue to lung as dissolved bicarbonate. 15-20% of co2 transported directly bound to hb. Co2 binds to n terminus of each subunit which releases protons (impacts ph: also contributes to bohr effect. 2,3-bisphosphoglycerate (bpg): small organic molecule which is very -vely charged. Negative allosteric effector of o2 binding by hb, decr o2 affinity.
