BCHM 316 Lecture Notes - Lecture 12: Dihydroxyacetone Phosphate, Lipoprotein Lipase, Glycerol Kinase
23 Feb 2018
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Document Summary
Pancreatic lipases: triglyceride monoglyceride + 2 fas. Pancreatic lipase does not go all the way. In the liver: glycerol acts as a gluconeogenic precursor glycerol l -glycerol -3-phosphate via glycerol kinase. L -glycerol -3-phosphate dihydroxyacetone phosphate via glycerol phosphate dehydrogenase. Nad+ gets converted to nadh and h+ Dihydroxyacetone phosphate goes into gluconeogenesis via glyceraldehyde-3- phosphate. Chylomicrons carry exogenous lipids to tissues in the body, then to the liver to be made into vldl. Pancreatic lipases degrade dietary fats in the gut. Fat is broken down, then reassembled and put into chylomicrons. Tg 2-mg + 2fa , broken-down products can cross gut wall. Tg is mixed with food need lipid emulsion, pl is heavy-duty so it is resistant to proteases. Lipid emulsion requires bile salts -- this increases the ph to optimal levels (like 7) Bile salt: taurocholic acid, natural detergent, breaks fat into micelles. Coats outside of triglyceride ( sulfate group is charged and exposed to solvent) + soluble.
