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Class Notes for Biochemistry at Queen's University

BCHM 310 Lecture 35: BCHEM 315 12:3
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BCHEM 315 123 3. integral membrane proteins: cross thru lipid bilayer w an intra + extracellular domain Domains outside of lipid resemble soluble proteins Regions in contact w lipids - Hydrophobic side chains - H bonding s...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 34: BCHEM 315 12:2
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BCHEM 315 122 Allosteric control- Aspartate Transcarbamoylase (ATCase) - Catalyses 1 step unique to pyrimidine biosyn (CTP, UTP, ect) Cystidine triphosphate (CTP) ATCase structure - Two trimers of catalytic subunits, wedge...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture Notes - Lecture 32: Tev Protease, Cysteine Protease, Oxyanion
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BCHEM 315 113 Oxyanion hole: holepocket where oxyanion can form the 2 H-bonds - Pocket in which backbone NH can donate H bonds to the oxyanion of TS and tetrahedral intermediate (not to S in ES complex) - Enzyme using bind...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 33: BCHEM 315 12:1
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find more resources at oneclass.com BCHEM 315 12/1 Aspartyl protease mechanism - No covalent catalysis - Orientation + proximity effects - Acid/base cataly...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 31: BCHEM 315 11:2
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find more resources at oneclass.com BCHEM 315 11/2 Serine Proteases - Chymotrypsin, trypsin - Recognition pocket- defines specificity of the substrate ...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 29: BCHEM 315 10:3
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find more resources at oneclass.com BCHEM 315 10/3 Michaelis-Menten Equation Vo=Vmax[S]/(Km+[S]) - Describes rectangular hyperbola relationship b/n an enzyme and S for an ...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 28: BCHEM 315 10:2
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find more resources at oneclass.com BCHEM 315 10/2 How to incr rx rate? Uncat rx Reaction rate profile diagram SES formation of ES complex, desolvation of E + S ESEP true tra...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 27: BCHEM 315 10:1
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find more resources at oneclass.com BCHEM 315 10/1 2 His and a Lys interacting w 2 phosphates in BPG ans: A Enzymes Proteins that ...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 26: BCHEM 315 9:3
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BCHEM 315 93 Peripheral tissues - Increase in [H] leads to pH of 7.2 means that His146 is protonated and have electrostatic interaction bn His and Asp94 stab the T state lung - Decr in [H] leads to a pH of 7.6, His 176 is ...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 25: BCHEM 315 9:2
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BCHEM 315 92 At lung have a high pO2- 12kPa In tissue pKa is 4 Co-operative effect allows us to bind O2 efficiently in lung and release O2 efficiently in tissue - Simplistic, reversible binding is not sufficient Quantitati...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 24: BCHEM 315 9:1
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find more resources at oneclass.com BCHEM 315 9/1 Hb - Located in RBC - 1/3 of mass of RBC corresponds to Hb - O2 transport + CO2 transport - 4 stru...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 23: BCHEM 315 8:3
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find more resources at oneclass.com BCHEM 315 8/3 AFP summary - Huge variety of 3D folds - Mostly repetitive in seq + structure - All have 1 face that is...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 22: BCHEM 315 8:2
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find more resources at oneclass.com BCHEM 315 8/2 Type I AFP - 37aa a-helix - DN have any large hydrophobic groups for hydrophobic effect or DN have 3 structure...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture Notes - Lecture 21: Immunoglobulin G, Immunoglobulin Heavy Chain, B Cell
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BCHEM 315 81 Ab diversity - Germ like DNA for a light chain - V1 V2 V3. V300 J1 J2 J3 J4 recombination w VJ and C added V19 J2 C o V19 J2 make up VL and C makes up CL part - 300*4= 1200 combinations - Errors during recombo...

Biochemistry
BCHM 310
Robert Campbell
BCHM 310 Lecture 19: BCHEM 315 7:1
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find more resources at oneclass.com BCHEM 315 7/1 Function: allows for adaptability + functional promiscuity - Role in transcription and translation, which are tightly r...

Biochemistry
BCHM 310
Robert Campbell

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