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Lecture 11

BIOL 103 Lecture Notes - Lecture 11: Natural Killer Cell, Gastric Acid, Flagellin

Course Code
BIOL 103
Virginia K Walker

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43.1 In innate immunity, recognition and response rely on traits common to groups of
pathogens (pg 995-1000)
-Innate immunity= found in all animals and plants (invertebrates only have this)
-In vertebrates, can act as rapid defence or as foundation for adaptive immune defence
Innate Immunity of Vertebrates
-Rely on exoskeleton as first line of defence by providing an effective barrier against most
-Chitin-based barrier also found in insects intestine (block infection by pathogens found in
food) + lysosome (breaks bacterial cell wall)
-hemocytes- immune cells that travel in the hemolymph=insect’s circulatory fluid
1) Phagocytosis of bacteria
2) Trigger production of chemicals that kill pathogen or trap parasites Eg. Plasmodium
3) Antimicrobial peptides- short chains of amino acids and circulate in the body of the
insect to inactivate or kill foreign material by disrupting the plasma membrane
-Immune cells of insects only bind to molecules found on outer layers of fungi
(polysaccharide) or bacteria (polymers with sugars and amino acids)= markers for
pathogen recognition from insect recognition protein
Ex: Fungus “Neurospora crassa” infect fruit flies- recognition protein+fungal wall=protein
Toll receptor- signal transduction on surface of hemocytes to synthesis antimicrobial
peptides to fight against fungi
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