BIOL 205 Lecture Notes - Lecture 2: Phenylalanine Hydroxylase, Null Allele, Royal Jelly

• School: Queen's University
• Department: Biology
• Course: BIOL 205
• Professor: Ian Chin- Sang

Document Summary

We only carry two alleles, one from mom and one from dad. Change in sequence -> simplest one is a base pair change, can knock out a gene completely. Any change in sequence is known as a mutation (silent to loud) Alleles can have several points of mutation. Allele : one of many variants of a gene. Simplest mutation is a base pair change (e. g. g-c to a-t) Others include single bp insertion, small deletion, large deletion, inversions, etc/ Silent (silent mut, diff bp same amino acid) Intermediate (diff protein, diff func, no loss of func. ) Genomes are identical, but queen bee received royal jelly. Workers die off in weeks, queen lives for years. This recessive disease is caused by a defective allele of the gene that encodes a liver enzyme called phenylalanine hydroxylase. Gene that encodes the enzyme is haplosufficient. If we lack this enzyme, we cannot synth.