Health 101 Topic 8 Combatting Infectious Diseases (abstract) INTRODUCTION -a healthy immune usually is effective in combating disease -few infections require anitibiotics/antivirals 1/ THE IMMUNE RESPONSE -divert/destroy 2 categories: a) N

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16 Oct 2011
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TOPIC 8. COMBATTING INFECTIOUS DISEASES
INTRODUCTION
-a healthy immune usually is effective in combating disease
-few infections require anitibiotics/antivirals
1/ THE IMMUNE RESPONSE
-divert/destroy
2 categories:
a) Non-specific
-innate, natural response
-developed from birth
-no recognition of specific microbes
-little improvement over time
-it includes: 1) Physical Barriers (ie. skin, mucous membranes)
2) Active Removal (ie. urinary flushing, mucsal
escalator system: cilia in upper respiratory tract)
3) Destruction (ie. lysozymes in tears, acids in GI tract,
phagocytosis, monocytes, neutrophils, and
macrophages)
-inflammatory response: reddening, swelling.
Monocytes, neutrophils eat up microbes. Rapid (1-2
hrs). Reduces microbe proliferation.
-fever: temperature rises 2 degrees when fighting
infection
-lactoferrin (prevents iron binding: microbes need iron
to survive)
b) Specific
-acquired, adaptive response
-used if nonspecific system fails
-requires recognition of specific microbes
-develops from experience
-efficient improvement over time
-slower (if it is the first exposure)
-relies on antigens (can be specific (ie. 1 amino acid in a protein)
or a molecule (ie. molecular fingerprints))
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