HLTH 230 Lecture Notes - Lecture 7: Macular Degeneration, Thrombin, Rickets

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*folate and b12 require each other - symbiotic relationship. Helps breakdown some fatty acids and a. a: vitamin b12 and folate are closely related (depend on each other for activation) B12 participates in removal of methyl group for activation of folate coenzyme. *if b12 is not bound to intrinsic factor, receptors do not recognize b12 for absorption. =>need intrinsic factor to absorb b12!: recommendations. Only a very small amount required: 2. 4 micrograms (very little!!: deficiency. Generally results from poor absorption, not poor intake. Inadequate absorption is likely due to either (secondary deficiency): Lack of hcl acid (b12 not released from dietary proteins) Lack of intrinsic factor (b12 is not recognized for absorption) Deficiency is common in the elderly due to atrophic gastritis. Atrophic gastritis (inflammation of stomach): common in older adults. May also occur as a result of iron deficiency or infection with helicobacter pylori.

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