MICR 121 Lecture Notes - Lecture 6: Beta-Lactam, Penicillin Binding Proteins, Structural Analog

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 121
• Professor: Prameet Sheth

Document Summary

Micr120 lecture 6: antimicrobial compounds and resistance mechanisms. Midterm: all short answer, 9-11 questions, 2 hours (lab material is testable), can write in pt form, case-based. Sensitive (cid:449)he(cid:374) o(cid:396)ga(cid:374)is(cid:373)s (cid:396)espo(cid:374)d to a(cid:374) a(cid:374)ti-microbial and has activity in vivo (aka susceptible) Antimicrobial targets: dna: prevent bacteria from replicating, ribosome: selective inhibition of protein synthesis. Cell wall: beta lactams are largest group; include penicillin; act on cell wall (not on the protein or nucleic acid) Cell membrane (polymxtin) colastin (super powerful detergent; last resort antibiotics; can cause death) there are resistance strains (getting it from chickens) The beta-lactam ring is the central component of all beta-lactam antibiotics: all are broad spectrum bacteria: Target: cell wall: antibiotics in this class include: penicillins, amoxcillin, They work by inhibiting cell wall synthesis: beta lactam ring = allows it to interfere with cell wall synthesis, nam and nag get together and cross-link to form peptidoglycan layer, beta-lactam interferes with this (punches holes in it)