MICR 221 Lecture Notes - Lecture 7: Pilus, Cell Membrane, Pilin
12 Nov 2016
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Document Summary
Bacterial proteinaceous appendages: locomotion: flagella, adherence factors: pili, conjugal transfer of dna: sex pili. Found in gram negatives but rare in gram positives. Composed of 1000 copies of major pilin (protein) in the shaft and a small amount of adhesion at the tip. Drug companies often make vaccines against pilli in pathogens to stop the adhesion of pili to the human cells which leads to infection of the cell. Pili are differentiated by their receptor (what the adhesion bind to) Found in the digalactose of glycolipid cells lining the urinary and gi tract. Pap e, f,g: g is the actual adhesion, f is needed to couple papg to the pilus fibrillum and e is the major component of the fibrillim. Papc in the outer membrane, it removes the proteins from papd. Papd acts as a chaperone between the cytoplasmic membrane and the outer membrane. Pilus subunits must be transported across both the cytoplasmic membrane and the outer membrane.
