MICR 221 Lecture Notes - Lecture 25: Monolayer, Methylene Blue, Hela
24 Apr 2018
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Document Summary
Particles are prod from assembly of pre-formed components. Virus particles (virions) dn grow or divide. Usually dn encode info for e prod, ribosomes, trnas, lipid memb synthesis: build small particles to contain nucleic acid genome, have small genomes (<100 genes, often <10) ex. polio has 1 gene polyprotin to perform diff functions. Infectious cycle: particles bind to cells, enter, release genome, decode genome, rep, build particles and exit cells: establish relationships w host- benign to lethal, overcome host defenses w comparative ease. Mosaic virus: causes stripping in tulips, many buried in poo ect in glacial ice now being dethawed. Can drive evolution, provide direct or indirect advantages to host survival. Wasp injects eggs and polydnavirus into worm, polydnavirus infects worm hemocytes preventing them from destroying wasp eggs, genome wasp virus are encoded in worm, wasps want to be used as natural insecticide. Humans: 8% of genome comprised of hervs (human endogenous retroviruses) footprint of ancient germline retroviral infections.
