MICR 360 Lecture Notes - Lecture 28: Apoptosis, Ankylosing Spondylitis, Rheumatoid Arthritis
Document Summary
Type 2 is cell membrane associated self antigen; type 3 is circulating soluble s elf-a ntigen;type. 4 involves t cells that recognize self peptides bound to mhc molecules on the cell membrane. Makes sense that they all have self in them because it is an autoimmune disease. Autoimmune disease : caused by an immune response mounted by the individual self-antigen. There is relative risk with certain mhc types. How do you calculate relative risk? elative risk frequency of disease with the hla frequency of the disease without hla. Association of autoimmune diseases with alleles of the mhc locus. Relative risk of developing an autoimmune disease in individuals who inherit particular hla allele(s) compared to individuals lacking these alleles. So individuals who have the hla-b27 allele are 90 times more likely to develop the disease ankylosing spondylitis than b27-negative individuals. So individuals who have the hla-dr4 allele are 4 times more likely to develop rheumatoid arthritis than dr4-negative individuals.