MICR 360 Lecture 24: MICR 360 9:2

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

Effector molecules= perforins, granzymes serine esterases, ifngamma, lymphotoxin- Perforin/fas polymerizes to forms a pore to allow granzyme (serine proteases) entry and induce cell apoptosis. Perforin mutation= intact effector bc fasl (on cd8) can bind fas (cd95) on target to induce apoptosis, but decr killing of target cells. T cells must be active and can only kill targets that exp the same mhc molecules. First injected mouse w virus to act t cells took t cells from spleen and incubated w virus infected cells labelled w chromium measure chromium prod, more=lots of killing. Cmi t cells cd4 th1: exogenous ag presented by mhc. Na ve t cells in lymphoid organs ref ag prolif + diff go to circulation effector t cells in tissues act macro or kill target cells. On macros, sr, complement r (c3b), mannose r, dectin-1 (interacts w yeast), lipid.