MICR 360 Lecture 30: MICRO 360 11:2
22 Dec 2018
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Document Summary
Screened by: blood counts, ig levels, efficacy of immune response. Chronic granulomatous disease (cgd): defects in phagocyte oxidase making roi impairs killing recurrent intra bacterial + fungal infections. Complement immunodeficiency: lack of c3b= impaired immune complex clearance + phago. Digeorge syndrome: thymus dn develop, so absence of t cells susceptible to viral + fungal infection, live vaccines can be life-threatening. Bruton"s disease: defect in bth impairs b cell development, low or no ab, small lymph nodes, symptoms after 3 months when mother"s passive immunity wears off. Hyper-igm syndrome: defect is t cell dependent b cell activation, mutation in. Cd40l defective switching of b cells to iga/g isotypes so compensatory incr in. Igm so susceptible to infection + intra microbe (pneumocytosis carinii) Common variable immunodeficiency (cvid): hypogammaglobulinemia, mature b fail to diff into plasma cells, decr igg/a. Treatment= iv injection of ig (ivgg) for chronic recurrent infection.
