MICR 360 Lecture 29: MICRO 360 11:1
22 Dec 2018
School
Department
Course
Professor
Document Summary
Tumor/neoplasm: loss of control of cell cycle, caused by mutation, chem, pesticides, radiation or viral infections (ebv, hhv: benign: non-invasive in surrounding healthy tissue, malignant: invasive, indefinite growth, metastasize. Abnormal act of proto-oncogenes: ras for cell signalling and diff. Defects in apoptosis gene: bad for reg programmed cell death. All ifn enhance anti-tumor cell activities- type i ifn can induce tumour cell death. Tumour antigens: tumor-specific ag (tsa): ag encoded by genes exclusively exp by tumors, tumour associated ag (taa): overexpressed ag or inapprop exp of ag that should be exp at a certain stage of development. Innate: loss of nk cell activities due to mutation (nk detect lack of mhc exp) can cause cancer + activated macro secrete tnf-a (strong anti-tumor) Adaptive: lack of tumor-infiltrating lymphocytes (tils) can cause cancer. B cells gen anti-tumor ab against tumor-specific ag: promote tumor-cell rec + lysis. Chronic inflam: incr cellular stress signals + mutation rates.
