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Class Notes for Microbiology and Immunology at Queen's University

MICR 360 Lecture 12: MICRO 360 Igs
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find more resources at oneclass.com H chain Effector Functions Image IgG Gamma ADCC, Dominant + crosses placenta 4 ...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 32: MICRO 360 12:1
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find more resources at oneclass.com MICRO 360 12/1 TRANSPLANTS Transplants Kidney, bone marro...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 29: MICRO 360 11:1
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MICRO 360 111 Tumorneoplasm: loss of control of cell cycle, caused by mutation, chem, pesticides, Cancer radiation or viral infections (EBV, HHV) Benign: non-invasive in surrounding healthy tissue Viral agent Cancer Malign...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 30: MICRO 360 11:2
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find more resources at oneclass.com MICRO 360 11/2 Immunodeficiencies Primary: gen...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 31: MICRO 360 11:3
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MICRO 360 113 VACCINES Cowpox: vaccine for smallpox discovered by Jenner, eradicated small pox by 1980 Antigenic cross-reactivity: cowpox + smallpox have similar surface Ag Tri-vaccine: measles-mumps-rubella (MMR) immuniza...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 20: MICR 360 7:3
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MICR 360 73 Positive + Positive: ensures MHC restriction to become single positive (CD4 or 8), selects negative thymocytes w TCR capable of binding self peptides, if TCR can bind MHC II it also selection binds CD4 committi...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 28: MICRO 360 10:3
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MICRO 360 103 Autoimmune diseases Rare immune response mounted by the indiv against self Ags, involves type II Ex= Ankylosing spondylitis, Rheumatoid arthritis, Insulin-dependent diabetes, Pemphi Indiv w HLA-B27 allele are...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 27: MICRO 360 10:2
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find more resources at oneclass.com MICRO 360 10/2 Type II IgG mediated in minutes, Ab react to surface Ag via ...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 26: MICR 360 10:1
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MICR 360 101 Hypersensitivity Hypersensitivity Excessive immune response assoc w allergic rxs which lead to undesirable consequences Atopy Tendency of an indiv to develop immediate hypersensitivity mediated by IgE Ab to va...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 24: MICR 360 9:2
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MICR 360 92 CMI CD8 MTOC organizes cell components for polarization cytokine release Effector molecules= perforins, granzymes serine esterases, IFNgamma, Lymphotoxin- TNF-B PerforinFas Polymerizes to forms a pore to allow ...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 22: MICR 360 8:2
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find more resources at oneclass.com MICR 360 8/2 Humoral immune response B cell 1. B cell precursor rearranges Ig genes develop 2. immature B bound to self Ag removed from review r...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 23: MICR 360 8:3
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find more resources at oneclass.com MICR 360 8/3 Cytokine 1. TH adheres to B cell and begin to syn IL-4 secretion and CD40 ligand, immunological synapse, mechanism MTOC is the cen...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 24: MICR 360 9:1
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MICR 360 91 Cell mediated Immunity (CMI) Effector cells Ag specific: cytotoxic T + helper T (TH1) Ag non-specific cells: NK + macro Viruses in cytosol exp on MHC I and act CD8 cytotoxic T to kill infected cell Bacteria in ...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 25: MICRO 360 9:3
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MICRO 360 93 Immunological memory Phases of 1. Establishment of infection- APC prime nave T cell which migrate to host- lymph node microbe 2. Inductive phase of adaptive 3. Effector phase to clear the infection- 7 days, TC...

Microbiology and Immunology
MICR 360
Sameh Basta
MICR 360 Lecture 21: MICR 360 8:1
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MICR 360 81 TCR signaling Initiated by CD45R interacting w CD22 act P56lck act NF-kB effector activites (CD8 for cytotoxic, CD4 for cytokine prod) CD28 binds B7 Enzymes which reg signaling Kinases= P proteins phosphatase: ...

Microbiology and Immunology
MICR 360
Sameh Basta

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