PATH 310 Lecture Notes - Lecture 2: Antibody, Anaphylaxis, Endonuclease

• School: Queen's University
• Department: Pathology and Molecular Medicine
• Course: PATH 310
• Professor: Christine Hough

Document Summary

Diagnosis of coagulopathies: coagulopathy: a condition in which the blood"s ability to coagulate (form clots) is impaired, this condition can cause a tendency toward prolonged or excessive bleeding, to diagnose coagulopathies: we must obtain a plasma sample. Serum is devoid of the coagulation factors, we need the plasma. To test for hemophilia: take a plasma sample and measure factor 8 and 9 levels. Population frequency: both hemophilia a and b are very rare disorders, hemophilia a: affects 1 in 5,000 males, hemophilia b: affects 1 in 25,000 males. Canadian hemophilia registry (2014: population of canada 36 million, hemophilia a: 3017, hemophilia b: 699. Inheritance of hemophilia: monogenic x-linked recessive disorder, monogenic: only one gene is affected, x-linked recessive disorder, mostly males affected because they don"t have a normal x to make them just a carrier. If a male has hemophilia, all his daughters will be carriers, and all his sons will be normal.