PATH 310 Lecture 11: Intro to Cancer II
20 Mar 2017
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Document Summary
Intro to cancer ii: activated form leads to cancer, typically through overexpression or activating (dominant) mutation. Tumour suppressor: loss of function leads to cancer, point mutations, deletions, gene rearrangements, accompanied often by loss of heterozygosity. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through. Darwinian selection: vhl: early driver mutation, almost everything else that"s happened, happened independently along the metastatic line and primary tumour line, the division where those metastatic cells genetically diverge is early on in the pathway, big challenge. Dna damage, the damaged dna will keep replicating. The balance between proliferation and apoptosis: p53 tips the balance in presence of dna damage to apoptosis instead of s phase, but we don"t have 1 or 2 mutations, we have 100s.
