PATH 310 Lecture Notes - Lecture 2: Bispecific Monoclonal Antibody, Recombinant Dna, Thrombophilia
28 Sep 2017
School
Department
Course
Professor
Document Summary
The extrinsic pathway is switched off with. Tfpi (tissue factor pathway inhibitor) after the pathway is started. * this pathway is regulated with a negative inhibitor. The intrinsic pathway is an amplification pathway in which thrombin is used as positive feedback. Blood coagulation does not occur in the fluid phase but is limited to phospholipid surfaces, present to areas of vessel damage and surfaces of endothelial cells. Complexes usually involved an enzyme, cofactor, and substrate. The complex produces the next enzyme in the cascade of blood coagulation. * at plasma levels lower than 5% spontaneous bleeding occurs frequently: provoked bleeding. Factor viii/ix replacement: critical bleeding events rare. Must be administered intravenously and can be derived from . Transmission of infectious agents: prions, unknown agents. Hemophilia treatment approaches: on demand at time of bleeding, prophylactic to prevent bleeding. It was seen that the preventative (prophylactic) method decreased the amount of join hemorrhages and the overall number of hemorrhages.
