PATH 310 Lecture Notes - Lecture 1: Vascular Smooth Muscle, Thrombomodulin, Endothelium

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Document Summary

Hemostasis is the normal process that stops bleeding after vessel injury with the formation of a hemostatic plug. It is rapid, controlled, site specific, and removed. Components of blood erythrocytes, leukocytes, platelets, and plasma. Blood vessels endothelial lining, smooth muscle cells, fibroblasts, vessel walls. To keep blood in a fluid state you need : an intact vascular endothelium. Regulates vascular tone, vascular smooth muscle cell proliferation, and trans- endothelial leukocyte migration. Also plays a role in thrombosis and thrombolysis (through prothrombic components tf, vwf, and collagen) There are molecules on resting endothelial cells: platelets in a quiescent state. Cd39/adpase is a platelet antagonist: regulation of coagulation. Activators of coagulation: coagulation activation, endothelial damage, platelet activation. Inhibitors of coagulation: anticoagulant factors, endothelium, fibrinolytic factors. It also produces a protein c/s complex that limits coagulation factors fv and fviia: regulation of fibrinolysis t-pa and uk converts plasminogen to plasmin in order to break down fibrin.

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