PATH 310 Lecture Notes - Lecture 3: Low-Density Lipoprotein, Nfe2L2, Shear Stress
28 Sep 2017
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Document Summary
A complex disease heavily influenced by environmental factors. Disease of elastic and muscular arteries (large to medium sized vessels) Lose of arterial elasticity vessel thickening and stiffening. * the plasma of individuals with atherosclerosis is very milky due to elevated lipids (ldl cholesterol bad fat) * architecture of arteries can also lead to atherosclerosis, which doesn"t depend on ones diet but is genetic. The first lesion is called the fatty streak. The development of the lesion occurs between the endothelial cells and the smooth muscle cells. * it is characterized by a build-up of lipids, cholesterol, calcium, and cellular debris. As the plaque gets bigger it hardens and starts to occlude the lumen. This limits blood flow and tissues downstream don"t get enough oxygen (cid:523)ischemia(cid:524: smooth muscle cells (express tf, elastin, endothelial cells, subendothelial matrix (contains vwf) The plaque can rupture and lead to a very large thrombosis. * plaques can lead to endothelial dysfunction and vascular inflammation.
