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Class Notes for Pathology and Molecular Medicine at Queen's University

PATH 310 Lecture Notes - Lecture 3: Low-Density Lipoprotein, Nfe2L2, Shear Stress
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ATHEROSCLEROSIS A complex disease heavily influenced by environmental factors Disease of elastic and muscular arteries (large to medium sized vessels) Lose of arterial elasticity  Vessel thickening and stiffening * The ...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 1: Vascular Smooth Muscle, Thrombomodulin, Endothelium
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HEMOSTASIS – is the normal process that stops bleeding after vessel injury with the formation of a hemostatic plug - It is rapid, controlled, site specific, and removed Components of Blood – Erythrocytes, leukocy...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 2: Bispecific Monoclonal Antibody, Recombinant Dna, Thrombophilia
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- The extrinsic pathway is switched off with TFPI (Tissue Factor Pathway Inhibitor) after the pathway is started. * This pathway is regulated with a negative inhibitor - The intrinsic pathway is an amplifica...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 22: PATH 310 W11L1
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 24: PATH 310 W12L1
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 23: PATH 310 W11L2
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 20: Huntington's disease
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 17: Fot
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 19: ALS neuropathology
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Beuheg 4 disease (baseball player most comaron cause Canada 2 loo per year Less than 10/ mo oure, 1001. Patal to cautico penal teact spinal es then divides e lateial and ante little muscle tame Beuheg 4 disease (baseball ...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 18: Reduced Mass
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Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 21: Crispr
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or non-code S-30 3S- TO L leading st and eng DNA malep a loop HTT mee to determine CAG nene at 1 ria PCR L little ethnic. un onset of. or non-code S-30 3S- TO L leading st and eng DNA malep a loop HTT mee to determine CAG...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 12: Acute Leukemia
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Acute Leukemia Stem Cells Capable of selfrenewal (although this is a rare event and stem cells are mainly quiescent) Are multipotent (i.e. can give rise to a remarkable number of daughter cells by committing to successive ...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture 10: Intro to Cancer I
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Intro to Cancer I Cancer A disease in which abnormal cells divide without control and are able to invade or spread to other tissues Cancer is a growing problem, there is an increased risk in developing cancer Cancer death ...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 15: Polymerization, Dasatinib, Reverse Transcription Polymerase Chain Reaction
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add chemical to add tissue stimulate mitosis sample incubate for 2-3 days Culture in a growth medium cut out chromosome dentify and pictures and arrange photograph chromosomes into karyotype 13 14 add chemical to stop mito...

Pathology and Molecular Medicine
PATH 310
Christine Hough
PATH 310 Lecture Notes - Lecture 14: Mesylate, Protein Dimer, Intrinsically Disordered Proteins
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lymphoid progenitor multipotent multipotent hematopoietic hematopoietic progenitor stem cell Common myeloid progenitor STEM CELL COMMITTED PROGENITORS NK cell THYMUS Tcell B cell dendritic cell dendritic cell macrophage mo...

Pathology and Molecular Medicine
PATH 310
Christine Hough

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