PHAR 100 Lecture Notes - Lecture 3: Serotonin Receptor Agonist, Gaba Receptor, Ethanol Metabolism
17 Oct 2017
School
Department
Course
Professor
Document Summary
The glutamate hypothesis of schizophrenia: glutamate: major excitatory neurotransmitter in brain, cognitive impairment and psychosis caused by hallucinogens (phencyclidine) which inhibit glutamate receptors (nmda types) Haloperidol: different chemical structure, blocks dopamine receptors, with similar pharmacological effects, lesser sedative and hypotensive effects, high propensity for producing extrapyramidal movement disorders, useful alternative for those who cannot tolerate/respond to phenothazines. May also be called/known as manic depressive disorder. Symptoms of manic phase: excitement, hyperactivity, disinhibition, aggression, some psychotic symptoms. Symptoms of depressive phase (similar to depression disorder): depressed mood, sleep disturbance, anxiety. High suicide risk associated with those with the disease. Alternatives to lithium as mood stabilizers: mood stabilizers: anticonvulsants valproic acid, carbamazepine, clonazepam, rapid onset action, thus often preferred, second-generation antipsychotics, combination of antidepressants (depressive phase) and antipsychotics (manic phase) Delusions and aggression in elderly with dementia. Bromides were first introduced into clinical medicine as sedatives and hypnotics in mid- Before, ethyl alcohol and herbal preparations were used.
