PHAR 100 Lecture Notes - Lecture 5: Urinary Tract Infection, Prokaryotic Small Ribosomal Subunit, Beta-Lactamase
17 Oct 2017
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1909: paul ehrlich concept of chemotherapy, designed organoarsenicals drugs, cure for syphilis. 1929: alexander fleming st. mary"s hospital london, england, discovered penicillin after noticing staphylococcus aureus wasn"t growing due to penicillin mold. 1935: gerhard domagk sulfonamide drugs, germany, effective against variety of bacterial diseases, major advance in medicine. 1939-1945: florey and chain, oxford university, isolated penicillin, treated patients with it due to gram-positive bacteria. 1943: selman waksman, rutgers university us, streptomycin = treats tuberculosis and other gram-negative microorganisms. Antibiotic: chemical substance produced by microorganisms that supresses growth of other microorganisms, and may eventually destroy them. Antimicrobial and antibacterial: more encompassing, include both compounds from natural sources (penicillin) as well as synthetic compounds (sulfonamides) Gram-positive and gram-negative bacteria classification of bacterial where bacteria are treated with gram"s stain and observed under a microscope to identify if they"re positive (take up colour) or negative (discoloured)
