PHAR 100 Lecture Notes - Lecture 1: Hypokalemia, Levonorgestrel-Releasing Implant, Follicular Phase

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Jeanne Mulder

Document Summary

Oral contraceptives refers to product containing both an estrogen and a progestin. Fixed combination -> fixed combo of estrogen and progestin are intended to be taken from 5th to 25th day of cycle (counting day 1 as onset of menses) Multiphasic -> fixed amount of estrogen and variable amounts of progestin. Continuous -> taken for 28 days each cycle with no drug free period, menstruation is eliminated. Mini-pill -> daily low dose of progestin is taken as long as drug is needed, efficacy is slightly less than combination products. Alter profile of plasma lipids, increasing risk of coronary vascular disease. Norplant implanted under the skin (effective for five years) Changes in duration of menstrual bleeding and breakthrough bleeding. Estrogen -> large does of estrogen taken with 24-72 hours interfere with follicular development, altering cervical mucus, altering sperm migration and inhibiting fertilization (plan b)