PHAR 100 Lecture Notes - Corpus Luteum, Combined Oral Contraceptive Pill, Progestin

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Toxicological issues: safety profile of a drug use for social-economic issues must be quite different, follow toxicity of these compounds quite closely. Controlled by hypothalamus that releases hormone that stimulates the pituitary to release lh/fsh. Are selective receptors for estrogen and progesterone in hypothalamus, endometrium. During cycle when estrogen (esp. ) and progesterone increases, it feedbacks to hypothalamus which releases gonadotropin releasing hormone no more fsh. One of them starts to grow much more quickly. This stimulates the growth of the endometrium (proliferative phase) Lh acts on ovary to release follicle and increases release of estrogen and progesterone. Once follicle is released (structure leftover: corpus luteum) Corpus luteum releases progesterone and estrogen stimulating endometrium to release nutrients (secretory phase) If pregnancy doesn"t occure, corpus luteum stops secreting progesterone and endometrium loses support of progesterone. Lining begins to be sloughs and menstruation occurs target drugs wherever there is a receptor. Inhibit estr/prog in endometrium endometrium stops making nutrients.