PHAR 100 Lecture Notes - Cannabinoid Receptor Type 1, Adenylyl Cyclase, Chemotherapy
3 Dec 2013
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Document Summary
Introduction: cannabis sativa, history, 2700 bc to 1800"s hemp used to make rope. 1980"s use began to stabilize that is no further increase in rate of smoking. Fourth most widely used drug in the world. 1996 arizona and california voters approved the use of marijuana for medical use. 1997 ont court allows epileptic to use marijuana. 1999 health canada announces clinical trials on cannabis. Health canada to provide a standardized product: ~ 40 thousand people are legally allowed to use marijuana. 1990 cb1 cloned and mapped: target for drug. 1992 anandamide: endogenous compound that uses the canaboid receptrors putative neurotransmitter. 2003 link between cb2 (on merkal cells?) receptors and inflammation. 2006 inhaled form of thc: in puffer, approved for neuropathic pain. 2012 vote to legalize recreational use in one us state. Another votes to legalize for medical use: canada: approved to treat nausea associated w/ cancer chemotherapy.
