PHAR 340 Lecture Notes - Lecture 24: Sedation, Catecholamine, Pheochromocytoma
25 Dec 2017
School
Department
Course
Professor
Document Summary
Propanalol blocks both beta 1 and beta 2 receptors. Baroreceptors: detect blood pressure drop and increase heart rate as a result. Epinephrine before phenotlamine: initial spike in blood pressure, followed by a drop, increase in heart rate. Epinephrine after phentolamine: decrease in blood pressure, increase in heart rate. Used for hypertension (prazosin) and congestive heart failure as well as benign prostatic hypertropy --- relaxes smooth muscle, aids urination. Competitive antagonists at beta 1 and beta 2 receptors. Cardiac beta 1 receptors: inhibits renin release. Prevents increase in heart rate and contractility ; decreases blood pressure. Ischemic heart disease (angina): slows down heart rate and reduces force of contraction, reducing oxygen demand of the heart. Cardiac arrhythmia: icrease refractory period of cardiac av node, reducing supraventricular tachyarrhythmia. Congestive heart failure if patient has impaired cardiac function (compensated by sns activity) Propanalol is metabolized in the liver, can"t give if patient has impaired liver function.
