PHAR 340 Lecture Notes - Lecture 21: Coronary Artery Disease, Benign Prostatic Hyperplasia, Phentolamine
23 Dec 2018
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Sympatholytic drugs (means it blocks to input of the sympathetic nervous system) Blocks all alpha r (a1+2) to drop bp + incr hr (b rs still active) When antagonist is admin its immediate effect depends on existing stim of rs. E before phentolamine: incr bp (rs in heart) then small drop (b2 in vascular beds) then. E after phentolamine: b1,2 w a1,2 blocked shows decr in bp. Benign prostatic hypertrophy (relaxes smooth muscle in prostate and base of bladder) Cause orthstatic hypotension, tachycardia (phentolamine), incr gi activity, impaired ejaculation, nasal congestion. Designed propranolol based on isoprenaline to treat agina but was a competitive b antagonist returned contractile force + hr to baseline but incr in hr from e remained. Lower hr and decr hrv, decr risk of death after mi. Treat hypertension: decr renin release, hr, cardiac contractility, incr venous capacitance which all lead to decr cardiac output but leaves a1- vasoconstriction intact.
