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Class Notes for Pharmacology and Toxicology at Queen's University

PHAR 100 Lecture Notes - Lecture 3: Psychoactive Drug, Tetrahydrocannabinol, Motor Coordination

I apologize for the last post, For this assignment, I have chosen the investigation Brain imaging study of the acute effects of 9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana...

Pharmacology and Toxicology
PHAR 100
Jeanne Mulder
PHAR 100 Lecture Notes - Lecture 7: Ephedra, Medicine Man, Ephedrine

GILLEN 81802 PHAR100 MIDTERM EXAM NOTES Module 1 Module Outline: Section 01: History of Drug Use and Development Section 02: Drug Development, Drug Trials, and Drug Advertising Section 03: Drug Action Section 04: Pharmacok...

Pharmacology and Toxicology
PHAR 100
Jeanne Mulder
PHAR 340 Lecture Notes - Lecture 30: Cromoglicic Acid, Prostaglandin D2, Beclometasone Dipropionate
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PHARM 304 111 Asthma Inflame of airways + incr resistance to airflow due to contraction of bronchiolar smooth muscle, mucosal edema, bronchiolar secretions Characterized by: shortness of breath, tight chest, cough, wheezin...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture 25: PHARM 340 9:2
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PHARM 340 92 Eicosanoids Eicosanoids Derived from eicosaenoic acid precursors, 20 carbon w double bonds Arachidonic acid (AA) 5 categories: PGE, PGF, prostacyclin, thromboxane, leukotriene History Semen contract uterine sm...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 28: Janus Kinase 3, Probenecid, Indometacin
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PHARM 340 102 How to treat rheumatoid arthritis (RA)? RA Autoimmune disease w limited joint function due to inflame synovial memb, destruction of bone, cartilage Anti-inflam Chemically heterogeneous, diverse mechanisms of ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 24: Sodium Nitrite, Purine, Acetylcholinesterase
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PHARM 340 91 Antidotal action continued Antidote CN poisoning: accelerates conversion of CN to thiocyanate (nontoxic) via accelerate transsulfurase which is speed up by admin sulfur donor (thiosulfate) conversion of NaNO2 ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 27: Vascular Smooth Muscle, Cytochrome C Oxidase Subunit Ii, Annexin
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PHARM 340 101 Drugs that affect Eicosanoids Stim biosyn Release of AA by phospholipase is the rate limiting step Stim of phospholipase incr eicosanoid formation Drugs that target this are not useful bc there are several ef...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 29: H1 Antagonist, Myenteric Plexus, Gastric Mucosa
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PHARM 340 103 What is Histamine and its importance? Resp sys pharmacology Autocoids bio sub syn near site of action and secreted locally over short duration, but can have systemic effects can be amine, peptide or lipid der...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 26: Ductus Arteriosus, Prostacyclin, Prostaglandin E2
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PHARM 340 93 Physiological effects of eicosanoids (synthesized by body but can also be synthetic) Platelet Stim for aggregation release of endoperoxide + TXA2 to aggregate platelets aggregation PGI2 from endothelial cells ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 23: Vasoactive Intestinal Peptide, Alosetron, Tegaserod
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PHARM 340 82 Neuromuscular Excitatory: Ach via M3 Rs, Substance P via NK2 Rs transmission Inhibitory: ATP for P2Y1 Rs, NO for soluble guanyl cyclase, vasoactive intestinal peptide for VPAC Rs NK2 antagonist blocks most of ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 21: Coronary Artery Disease, Benign Prostatic Hyperplasia, Phentolamine
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PHARM 340 73 Sympatholytic drugs (means it blocks to input of the sympathetic nervous system) Phentolamine Blocks all alpha R (a1+2) to drop BP + incr HR (B rs still active) When antagonist is admin its immediate effect de...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 24: Cytochrome C Oxidase, Cyanide Poisoning, Deferoxamine
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PHARM 340 83 Antidotal action Antidote Chelation of heavy metals: chelating agent forms bond w metal to decr complex w amount of metal avail for binding of tissue molecules metal-chelating poison agent complex excreted dec...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture 22: PHARM 340 8:1
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PHARM 340 81 Enteric neuropharmacology Gut function 2 most common reason for physician visit disorders IBS, slow transit constipation, gastroparesis, GERD Brain-gut axis Afferent innervation: spinal afferent (pain), vagal ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture 20: PHARM 340 7:2
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PHARM 340 72 Cholinergic Two types Indirectly acting: inhibit cholinesterase incr Ach avail Directly acting: M and N R agonist and antagonists N ganglionic stimulators or blockers Calabar bean ppl who vomited from it weren...

Pharmacology and Toxicology
PHAR 340
Thomas Massey
PHAR 340 Lecture Notes - Lecture 19: Cardiogenic Shock, Ritodrine, Terbutaline
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PHARM 340 71 Sympathetic drugs and their actions Phenylephrine Mydriatic- opthalmological exam (a1) Nasal decongestant, elevates systemic BP to combat hypotension Clonidine (a2- Antihypersensitive, acts presynaptically to ...

Pharmacology and Toxicology
PHAR 340
Thomas Massey

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