PHGY 210 Lecture Notes - Lecture 11: Metabolic Acidosis, Nephron, Kidney Disease

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Balance refers to regulation of hydrogen ions (h+) in bodily fluids. Removes it from solution: referred to the expression of h+ in a solution. [h+] = 10-ph: low ph = higher [h+, high ph = lower [h+, ph is a logarithmic scale 10-fold increase ph values. Neutral" around 7. 0: very little dissociated water in their ion forms, ph < 7 = acidic, more free [h+, ph > 7 = basic/ alkaline, less free [h+] Venous blood ph = 7. 35: acidosis = below 7. 35, alkalosis = above 7. 45. Increase plasma potassium from acidotic blood: more h+, k+ secreted, cause excitable cells to depolarize = more excitable. Production of h+ in body: from metabolic activity. Three primary sources: carbonic acid formation, metabolic by-product of cellular respiration = co2 and h2o, carbonic anhydrase converts co2 and h2o into carbonic acid (h2co3, dissociates into bicarbonate (hco3. Base + solution = binds to free h+, forward reaction = dissociates more h+

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